منابع مشابه
Exercise-induced airway constriction.
J. E. COTES Breathlessness is one of a number of symptoms which may limit exercise; it usually does so when the ventilation during exercise approaches a maximal value which is determined by interaction between the drive to respiration and the mechanical properties of the lung. Assessment is based in the first instance on the clinical interview and simple measurements of lung function. Depending...
متن کاملThe airway microvasculature and exercise induced asthma.
It has been proposed that exercise induced asthma is a result of "rapid expansion of the blood volume of peribronchial plexi" (McFadden ER, Lancet 1990;335:880-3). This hypothesis proposes that the development of exercise induced asthma depends on the thermal gradient in the airways at the end of hyperpnoea. The events that result in exercise induced asthma are vasoconstriction and airway cooli...
متن کامل325 Exercise-induced Airway Obstruction and Vitamin D Deficiency
322 Preoperative Cardiopulmonary Exercise Testing (CPET) in Severe Asthma Patients Ekaterini Syrigou, Anastasios Kallianos, Sotirios Tsimpoukis, Nektaria Makrilia, Ioannis Dannos, Fotis Psarros, and Kostas N. Syrigos. Department of Allergy, and; Oncology Unit, 3rd Department of Medicine, Sotiria General Hospital, Athens School of Medicine, Athens, Greece. Background: Lung resection is still the...
متن کاملThe GABAA agonist muscimol attenuates induced airway constriction in guinea pigs in vivo.
GABA(A) channels are ubiquitously expressed on neuronal cells and act via an inward chloride current to hyperpolarize the cell membrane of mature neurons. Expression and function of GABA(A) channels on airway smooth muscle cells has been demonstrated in vitro. Airway smooth muscle cell membrane hyperpolarization contributes to relaxation. We hypothesized that muscimol, a selective GABA(A) agoni...
متن کاملCytosolic phospholipase A2α mediates Pseudomonas aeruginosa LPS-induced airway constriction of CFTR -/- mice
BACKGROUND Lungs of cystic fibrosis (CF) patients are chronically infected with Pseudomonas aeruginosa. Increased airway constriction has been reported in CF patients but underplaying mechanisms have not been elucidated. AIM To examine the effect of P. aeruginosa LPS on airway constriction in CF mice and the implication in this process of cytosolic phospholipase A2alpha (cPLA2alpha), an enzym...
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ژورنال
عنوان ژورنال: Thorax
سال: 1969
ISSN: 0040-6376
DOI: 10.1136/thx.24.4.506-b